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Aciphex (Rabeprazole)
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Aciphex

Generic Aciphex is a high-quality medication which is taken in treatment of heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD). Generic Aciphex acts as by decreasing the amount of acid produced in the stomach. It is a proton pump inhibitor.

Other names for this medication:

Similar Products:
Pariet

 

Also known as:  Rabeprazole.

Description

Generic Aciphex is a perfect remedy in struggle against heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD).

Generic Aciphex acts as by decreasing the amount of acid produced in the stomach. It is a proton pump inhibitor.

Aciphex is also known as Rabeprazole, Pariet, Rablet.

Generic name of Generic Aciphex is Rabeprazole.

Brand name of Generic Aciphex is Aciphex.

Dosage

Take Generic Aciphex orally with or without food.

Do not crush or chew it.

Do not stop taking it suddenly.

Overdose

If you overdose Generic Aciphex and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aciphex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Aciphex if you are allergic to Generic Aciphex components.

Do not take Generic Aciphex if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Aciphex can harm your baby.

Generic Aciphex may interfere with certain lab tests.

Generic Aciphex should be used with extreme caution in Asian patients.

Generic Aciphex should be used with extreme caution in children younger than 12 years old. Safety and effectiveness in these children have not been confirmed.

Avoid alcohol.

Do not stop taking Generic Aciphex suddenly.

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To determine whether patients with LPR experience an improvement in symptoms before the complete resolution of the laryngeal findings.

aciphex 30 mg

On day 1 of treatment, rabeprazole relieved GORD symptoms across all grades of oesophagitis, with statistically significant (p = 0.0001) improvement in heartburn, regurgitation, epigastric pain and dysphagia. Oesophageal healing was achieved in 77% of patients at week 4 and in 90% at week 8 and treatment was well tolerated.

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The 14-day quadruple therapy with ranitidine bismuth citrate is effective and well tolerated for the patients who failed with the Helicobacterpylori treatment. The patients with older age may receive a more favorable outcome of the treatment.

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Fifteen Helicobacter pylori-negative volunteers, consisting of 5 homozygous extensive metabolizers (EMs), 6 heterozygous EMs, and 4 poor metabolizers (PMs) of CYP2C19, took 20 mg rabeprazole, 40 mg rabeprazole, and 20 mg rabeprazole plus 20 mg famotidine at bedtime (at 10 PM) for 8 days. The subjects then underwent 24-hour intragastric pH monitoring on day 8.

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To investigate whether overweight/obesity affects proton pump inhibitor pharmacodynamics when used in a single dose in patients with GORD.

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In GERD patients with nocturnal heartburn, a single oral dose of rabeprazole 20 mg increased intragastric pH more than pantoprazole 40 mg did throughout the 24 h after dosing.

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The reason that some reflux episodes evoke symptoms is poorly understood, therefore the aim of this study is to assess the determinants of reflux perception in patients with non-erosive reflux disease (NERD) on proton pump inhibitor (PPI) therapy.

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A total of 100 patients (33 males and 67 females, mean age=51.1 years) were enrolled. Eradication rate by PP analysis was 97.9% (47/48) with the 10-day SQT regimen and 87.8% (43/49) with 14-day STT regimen (97.9% vs 87.8%; p-value=0.053). Antibiotic susceptibility testing demonstrated 45% resistance to metronidazole, 14.8% to clarithromycin, and 24.1% to levofloxacin. CYP2C19 genotyping revealed 44.9% RM, 49% IM and 6.1% PM. IL-1B and IL-1RN genotypes were demonstrated as 21.4% for CC, 48.1% for TC, 36.8% for TT, 72.7% for 1/1, and 21.2% for 1/2 genotypes, respectively. The 10-day SQT regimen provided 100% eradication in patients with clarithromycin or dual clarithromycin and levofloxacin H. pylori resistant strains. Moreover, the 10-day SQT regimen resulted in a 100% eradication rate in all patients with CYP2C19 genotype RM and almost type of IL-1B (TC and TT) and IL1-RN genotypes ( 1/2 and other).

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aciphex 5 mg 2017-03-14

S-mephenytoin 4'-hydroxylase (CYP2C19) catalyses the metabolism of rabeprazole to some extent. Based on the metabolic and pharmacokinetic differences among other proton pump inhibitors such as omeprazole, lansoprazole and pantoprazole, rabeprazole buy aciphex appears to be the least affected proton pump inhibitor by the CYP2C19-related genetic polymorphism.

aciphex drug class 2015-05-06

To compare the effects of buy aciphex rabeprazole 10, 20 and 40 mg o.d. on 24-h intragastric acidity and plasma gastrin concentration in a randomized, double-blind placebo-controlled trial.

aciphex pills 2017-08-08

Two hundred and seventy-four patients were screened, 251 patients were randomized and 230 patients completed the trial. The numbers of patients with relief from heartburn on day 4 were similar in the two groups (84% for rabeprazole; 95% confidence interval, 76-90%; 83% for omeprazole; 95% confidence interval, 75-89%). There were no significant differences between the treatments in the relief from other gastro-oesophageal reflux disease symptoms or in healing rates. The number of reports of Zetia 10mg Generic severe heartburn during the first 3 days was higher in the omeprazole group (daytime heartburn: 4.7% for rabeprazole vs. 10.3% for omeprazole, P=0.005; night-time heartburn: 4.7% for rabeprazole vs. 9.8% for omeprazole, P=0.01; statistical comparisons defined post hoc).

aciphex maximum dosage 2017-05-17

Differences are emerging with respect to the mode of metabolism of proton pump inhibitors. All, except rabeprazole, are metabolised primarily by the hepatic cytochrome P450 enzyme system, and common genetic polymorphisms of the CYP 2C19 iso-enzyme affect their clearance and bio-availability. This has been demonstrated to lead to inconsistency in terms of acid suppression across the CYP 2C19 Celebrex Alternative Medication genotypes for all proton pump inhibitors except for rabeprazole. Omeprazole and, more markedly, esomeprazole, differ from the other proton pump inhibitors in that their bio-availability increases over the first week of treatment. This is due to a progressive reduction in their hepatic clearance with repeat dosing. This reduced hepatic clearance appears to be due to the S-enantiomer of omeprazole-esomeprazole impairing the activity of hepatic CYP 2C19. The clinical significance of these differences in metabolism of the various proton pump inhibitors, and the possible benefits of the non-enzymatic metabolism of rabeprazole, require further investigation.

aciphex generic name 2016-05-08

We investigated 53 patients with GORD symptoms and a various grade (A-C according to the Los Angeles classification) of reflux oesophagitis diagnosed in the course of upper endoscopy. By using 24-hour gastric and esophageal pH-metry we investigated the antisecretory effect of single-dose morning or evening administration of famotidine, omeprazole and rabeprazole. We revealed essential superiority of single-dose morning omeprazole and rabeprazole administration in daily gastric acid release suppression and Ventolin Tab 2mg gastro-esophageal reflux prevention as compared with morning famotidine and evening omeprazole and rabeprazole administration in GORD patients.

aciphex prices usa 2016-03-08

Rabeprazole and pantoprazole are both used for symptomatic treatment of gastro-oesophageal reflux Betnovate Dosage disease (GERD). Speed and duration of acid suppression and intensity of effect after a single dose may be important pharmacodynamic properties in clinical use.

aciphex max dosage 2016-06-15

Gastro-oesophageal reflux Naprosyn Tablets Ip disease has a chronic course, and often requires long-term treatment. Proton pump inhibitors are the treatment of choice for both acute and maintenance treatment, but little is known from randomized controlled trials of their effects beyond 1 year.

aciphex sprinkle dosage 2016-04-14

The pharmacokinetic parameters of rabeprazole were not altered by clarithromycin or verapamil irrespective of the CYP2C19 genotypes. However, this result shows that both clarithromycin and verapamil significantly influence the disposition of rabeprazole by inhibiting the oxidation of the thioether, since the AUC(0-infinity) of rabeprazole thioether that has no effect on acid secretion increased. Therefore, the pharmacokinetic interactions between rabeprazole and CYP3A4 or P-glycoprotein inhibitors have limited clinical significance Lanoxin Syrup Dosage .

aciphex sprinkle cost 2015-11-02

Proton pump inhibitors are the first-line treatment for reflux esophagitis. Because severe reflux esophagitis has very low prevalence in Japan, little is known about the effectiveness of proton pump inhibitors in these patients. This prospective multicenter study assessed the effectiveness of proton pump inhibitors for severe reflux esophagitis in Japan. Patients with modified Los Angeles grade C or D reflux esophagitis were treated with daily omeprazole (10 or 20 mg), lansoprazole (15 or 30 mg), or rabeprazole (10, 20, or 40 mg) for 8 weeks. Healing was assessed endoscopically, with questionnaires administered before and after treatment to measure the extent of reflux and dyspepsia symptoms. Factors affecting healing rates, including patient characteristics and endoscopic findings, were analyzed. Of the 115 patients enrolled, 64 with grade C and 19 with grade D reflux esophagitis completed the study. The healing rate was 67.5% (56/83), with 15 of the other 27 patients (55.6%) improving to grade A or B. No patient characteristic or endoscopic comorbidity was significantly associated with healing rate. Reflux and dyspepsia symptoms improved significantly with treatment. The low healing rate suggests the need of endoscopic examination to assess healing of reflux esophagitis at the end of therapy. (UMIN000005271).