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Risperdal (Risperidone)
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Risperdal

Risperdal is a medication with highly developed components which is taken in treatment of serious disorders such as bipolar disorder, mania, schizophrenia, and its symptoms. Risperdal can also be helpful for patients aged 5-16 with autism. Risperdal operates by giving brains balance and mental stability.

Other names for this medication:

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Also known as:  Risperidone.

Description

Risperdal is found by professionals of medicine to combat mental disorders (bipolar disorder, mania, schizophrenia and for patients aged 5-16 with autism). Target of Risperdal is to control and keep brain's balance. Risperdal operates by giving brains balance and mental stability.

Risperdal is atypical antipsychotic.

Risperdal is also known as Risperidone, Risdone.

Generic name of Risperdal is Risperidone.

Brand names of Risperdal are Risperdal, Risperdal Consta, Risperdal M-Tab.

Dosage

Risperdal is available in tablets (1 mg, 2 mg, 3 mg, 4 mg), liquid forms and in orally disintegrating tablets.

You should take it by mouth with meals of without it. Take it with water.

It is better to take Risperdal every day at the same time once or twice a day.

Risperdal can be given to patients aged 5-16 with autism.

Try to avoid drinking cola or tea together with Risperdal.

If you want to achieve most effective results do not stop taking Risperdal suddenly.

Overdose

If you overdose Risperdal and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Risperdal overdosage: muscle spasms, fever, fainting, sweating, convulsions, irregular or fast heartbeat, dizziness, feeling drowsy, blurred vision, upset stomach.

Storage

Store at room temperature between 15 to 25 degrees C (59 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Risperdal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Risperdal if you are allergic to Risperdal components.

Be careful with Risperdal if you're pregnant or you plan to have a baby, or you are a nursing mother.

Try to avoid drinking cola or tea together with Risperdal.

Try to avoid the state of being overheated.

Try to be careful with Risperdal usage in case of having liver, heart or kidney disease, seizures, Parkinson's disease, breast cancer, diabetes, angina.

Try to be careful with Risperdal usage in case of taking medications as valproic acid (Depakote, Depakene), antidepressants, paroxetine (Paxil), low blood pressure medicines, ranitidine (Zantac), clozapine (Clozaril), carbamazepine (Tegretol), Parkinson's Disease medicines as bromocriptine (Parlodel), pergolide (Permax), levodopa (Sinemet, Atamet, Dopar, Larodopa), ropinirole (Requip), pramipexole (Mirapex).

Elderly patients who are over 65 years should be very careful with Risperdal dosage.

Try to avoid medications caused drowsiness.

Avoid alcohol.

Be careful if you are going to have a surgery.

Avoid machine driving.

Do not stop take it suddenly.

risperdal starting dose

A single-dose, randomized, fasting, 2-period, 2-sequence, crossover study design with a 2-week washout period was conducted in 23 healthy Thai male volunteers. Blood samples were collected predose and at 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 5, 6, 8, 12, 24, 36, 48, 72 and 96 h following an oral administration of 2 mg risperidone. The plasma concentrations of risperidone and 9-hydroxyrisperidone were determined by using a validated HPLC method. Pharmacokinetic parameters of Test and Reference were obtained by noncompartmental analysis.

risperdal 300 mg

This open-label, multi-centre study enrolled 82 adults from four diagnostic groups (major depressive disorder (MDD), n = 25; bipolar disorder (BP), n = 21; dementia (DE), n = 20; schizophrenia (SZ), n = 16). Patients were switched from their previous dosage of compressed tablets (0.5, 1.0, 2.0, 3.0, or 4.0 mg/day) to an equivalent dosage of orally disintegrating risperidone and followed for 4 weeks. The primary effectiveness parameter evaluated was the Clinical Global Impression-Severity (CGI-S) scale.

risperdal dosing

The Czech Republic is faced with making choices between pharmaceutical products, including depot injectable antipsychotics. A pharmacoeconomic analysis was conducted to determine the cost-effectiveness of atypical depots.

risperdal drug classification

The National Institute for Health Research Health Technology Assessment programme.

risperdal 500 mg

RISPERDAL(®) CONSTA(®) is a long-acting, intramuscular formulation of risperidone microspheres for the biweekly treatment of schizophrenia and other psychiatric disorders. In a 24-month carcinogenicity study male and female Wistar Hannover rats received RISPERDAL(®) CONSTA(®) by intramuscular injection at dosages of 5 or 40 mg/kg once every 2 weeks. Bone changes described as "osteodystrophy" were observed by routine microscopic examination at 40 mg/kg in the sternum of female rats after 12 months, and in the sternum and stifle joint of both male and female rats after 24 months of treatment, respectively. To investigate the etiology of these bone changes, a 12-month mechanistic study was conducted in female Wistar Hannover rats at dosages of 5, 20 and 40 mg/kg once every 2 weeks. In addition to routine parameters, this study included bone markers, hormone measurements, and peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA) bone density measurements. It revealed a treatment-related reduction in metaphyseal trabecular bone density of the femur and tibia at 20 and 40 mg/kg, which was evident in the tibia from Week 13 of treatment onwards. There was no convincing evidence for any of the modes of action known to underlie trabecular bone loss in rats including renal, nutritional, or hepatic osteodystrophy, estrogen deficiency, hyperthyroidism or glucocorticoid excess. It is hypothetized that prolonged hyperprolactinemia accompanied by an increase in parathyroid hormone-related protein (PTHrP) levels and a slight hypoestrogenic state could have caused the reduced trabecular bone density in RISPERDAL(®) CONSTA(®)-treated rats. The relevance of this finding in terms of human risk is unknown.

risperdal tablet pictures

Most patients (24/25 MDD; 20/21 BP; 17/18 DE; 14/15 SZ) improved by 1 point on CGI-S from baseline or experienced no change at endpoint. Adverse events (AEs) occurring in any group at a > or =10% incidence included headache (19%) and pharyngolaryngeal pain (10%), reported in the BP group only.

risperdal pill

The objective was to investigate the relationship between in vitro and in vivo release of commercial Risperdal(®) Consta(®) microspheres. A modified USP apparatus 4 method was used for accelerated and real-time in vitro release testing. The in vivo plasma profile (clinical data) reported for the product was deconvoluted for comparison with the in vitro release profiles. The in vivo profile differed from the real-time in vitro profile and was faster initially and then slower after approximately 30 days. This effect is considered to be due to differences in the in vivo conditions such as small interstitial volume, low pH and immune response. Accelerated in vitro release profiles obtained at temperatures (50°C and 54.5°C) above the microsphere glass transition temperature (Tg∼48°C) overlapped with the in vivo profile after time scaling. A linear in vitro-in vivo relationship was observed with correlation coefficients of 0.97 and 0.99 at 50°C and 54.5°C, respectively. The accelerated test performed below the Tg had a similar release profile to that of the real-time in vitro test. The accelerated tests performed above the Tg of the microspheres showed the potential to be used for in vivo performance prediction as well as for quality control purposes.

risperdal online

The 90% confidence intervals for Test/Reference ratios of the pharmacokinetic parameters (Cmax, AUC0-t and AUC0-∞) of both risperidone and its active metabolite (9-hydroxyrisperidone) fell within the acceptable bioequivalence range (80 - 125%) according to ASEAN guideline.

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risperdal y alcohol 2016-10-23

Risperidone, an atypical antipsychotic, is used to treat mania both alone and in combination buy risperdal with other medicines.

risperdal overdose management 2015-07-22

Risperidone is a benzisoxazole derivate and buy risperdal is effective in the treatment of schizophrenia and other psychiatric illnesses in adults and children. Although there are a few reports in the literature regarding the pharmacokinetic characteristics of risperidone, insufficient data on its pharmacokinetic properties in a Chinese population are available.

risperdal 30 mg 2015-10-29

Risperidone is an atypical antipsychotic drug with potent serotonin and moderate dopamine antagonistic properties. It possesses good bioavailability following oral administration. Risperidone is primarily converted by the cytochrome P450 2D6 (CYP2D6) and 3A4 (CYP3A4) enzymes to 9-hydroxyrisperidone, its active Mestinon Iv Dose metabolite with equivalent potency to the parent compound.

risperdal 3 mg 2017-09-25

The data from this study in healthy adult male Chinese subjects suggest that the test formulation met the regulatory criteria for bioequivalence to the reference formulation, on the basis of the Cialis Soft Generic rate and extent of absorption. Both formulations were well tolerated.

risperdal overdose emedicine 2016-08-09

Schizophrenia is a chronic disorder, usually necessitating lifelong treatment. Although atypical antipsychotic agents have improved outcomes in schizophrenia, their clinical potential remains limited by patients' nonadherence to medication. Long-acting antipsychotics were developed in the 1960s to enhance treatment adherence and simplify the medication process. However, although conventional long-acting agents assure medication delivery, they are associated with similar side effects to their oral equivalents. The need for an agent combining the advantages of a long-acting formulation with those of an atypical antipsychotic was highlighted in 1997 Cefixime 75 Mg by the American Psychiatric Association's Practice Guideline for the Treatment of Patients with Schizophrenia. The first long-acting injectable atypical antipsychotic, long-acting risperidone (Risperdal Consta, Johnson & Johnson), has since been developed. This article discusses the efficacy, tolerability and cost-effectiveness of long-acting risperidone in schizophrenia and bipolar disorder patients, and suggests possibilities for how its role in clinical practice may change over the next 5 years.

risperdal yellow pill 2016-02-13

The purpose of this study was to develop an ideal microsphere formulation of risperidone that would prolong the drug release for 3 months in Propecia T Gel vivo and avoid the need for co-administration of oral tablets.

risperdal online 2016-12-01

This study is registered as Propecia Dose PROSPERO CRD42012002059.

risperdal tablet pictures 2015-01-02

Patients with psychoses/schizophrenia using atypical antipsychotics in tablet form perceive generic versions of their antipsychotics as being significantly different. This perceived difference lowers their intention Cardura Overdose Symptoms of continuing to take the medication, thus possibly jeopardizing treatment outcome. Caution with the generic substitution of atypical antipsychotics in the pharmacy is therefore recommended. Generic substitution should take place only with the knowledge and agreement of the psychiatrist and the patient.

risperdal medication dosage 2017-09-26

Poor adherence to pharmacotherapy during maintenance-phase treatment of bipolar disorder is a common occurrence, exposing patients to a high risk of illness relapses, rehospitalization and other negative outcomes. In view of this, there has been a reawakening of interest in the potential of long-acting injectable antipsychotic medications to improve treatment outcome during bipolar maintenance therapy. Indeed, long-acting injectable medications have practical advantages of assuring delivery of medication at a prescribed dose, and perhaps also making it easier to monitor adherence, at least to the long-acting drug. However, there are important limitations to the long-term use of depot typical neuroleptics in patients with bipolar disorder, including risk of extrapyramidal side effects and tardive dyskinesia, which may exceed that of patients with schizophrenia, and the potential for treatment-emergent exacerbation of depressive symptoms. Long-acting injectable risperidone (RLAI) has recently been approved for maintenance treatment in patients with bipolar I disorder. Evidence supporting the use of RLAI for this indication consists of several nonrandomized, open-label studies; one randomized, open-label trial; and two adequately powered randomized, double-blind trials. In general, these Voltaren Buy studies have shown RLAI to be effective for the prevention of relapse or hospitalization during bipolar maintenance treatment. In the double-blind studies, RLAI was associated with reduced relapse rates, increased time to relapse and greater control of clinical symptoms during maintenance treatment following initial stabilization, compared with oral medication treatment or placebo injection. RLAI appeared to be more effective for preventing manic/mixed episodes than depressive episodes. RLAI showed good tolerability across studies; however, dose-related extrapyramidal effects, sedation, weight gain and prolactin elevation may occur during long-term treatment. Responder-enriched designs and exclusion of important clinical subgroups in the double-blind trials may limit translation of these results to routine care settings.

risperdal user reviews 2015-08-09

The ODT manufacturing method was associated with time to disintegrate; the fastest were freeze dried tablets, followed by soft compressed tablets and then hard/dense tablets. Olanzapine Zydis(®) was the only ODT that completely disintegrated in less than 4 s for all strengths (5, 10, 15, and 20 mg), followed by 5-mg Prolanz FAST(®) (12 s) and then risperidone ODT 4 mg (40 s). Reasons for slow dissolution of the olanzapine generics may include low product potency, excipient binding, excipient solubility, active ingredient particle size and incomplete disintegration.